Dec 4, 2017 | By Tess

A team of scientists from the University of Alberta’s Ingenuity Lab in Canada have used 3D printing to create a leaf structure made from natural proteins and a printable hydrogel material. The project, says the team, brings them one step closer to creating an implantable 3D bioprinted organ.

Stella Mathews, chemical engineering researcher at U of A, holds the 4D printed leaf

(Image: Michael Brown)

In actuality, the 3D bioprinted leaf structure is more than just 3D printed, as the researchers have actually used a 4D printing technique for the bioprinted object, meaning that the leaf is able to physically react to different environments and materials.

The small leaf shape was 3D printed from a special resin made from silver nanoparticles, carbon nanotubes, and a membrane made of proteins. When the 3D printed leaf is submerged in water and exposed to a UV light, the materials in it react with the water and split the water H2O molecules to create hydrogen.

According to the researchers, this reaction gives the bioprinted form the same function as a hydrogen fuel cell, which produces heat, energy, and oxygen. From a physical standpoint, the leaf begins to swell when it is submerged in water and subjected to a UV light.

“We have expanded the set of tools to enable the incorporation of biological function as an intrinsic property in the devices we print with a new class of light-curable bio-nano ink,” explained Stella Mathews, a chemical engineering researcher at the U of A. “We call it 4D printing. It is the first step towards tissue engineering.”

The 3D printed leaf-shaped structure effectively demonstrates the ability to produce customized hydrogen fuel cells in a cost efficient manner. This in itself is exciting, but the researchers see the project as fitting into the bigger goal of 3D bioprinting implantable organs.

In other words, the 4D printed hydrogel leaf marks an important achievement towards the development of 3D bioprinted organs, though it may still be awhile before the first bioprinted heart is implanted. As Mathews told CBC, “We have stabilized one factor [of organ printing], which is among the thousands of factors.”

Currently, the Ingenuity Lab team is also working on 3D bioprinting a meniscus, which is the cartilaginous tissue that absorbs shock and protects your knee. Most people who have knee problems or knee pain will probably know all about the meniscus.

Existing treatments for a torn meniscus involved implanting tissue which has to be sized to the patient—usually during surgery. By being able to bioprint a custom-fitted meniscus tissue, Mathews says that knee surgery times could be greatly reduced, resulting in an easier recovery for patients.

“We would print it with a material that has the mechanical properties that can withstand the pressure of the bones, as well as have some factors that can promote cell adhesion, all while preventing the body’s immune system from rejecting the meniscus,” she explained. “But this is only phase one of many.”

Within that research project, the U of A team is moving ahead with testing the bioprinted meniscus tissue under pressure in order to determine how it might react within a human body.

The 4D bioprinting research was recently published about in the journal RSC Advances.



Posted in 3D Printing Technology



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